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1xbet 후기 (Otsuka) announces that we have entered into an exclusive, worldwide licensing agreement with Harbour BioMed for the development and commercialization of HBM7020, a BCMAxCD3 bispecific T-cell engager under development by Harbour BioMed. The license covers all territories worldwide except for Greater China (Mainland China, Hong Kong, Taiwan and Macau).

HBM7020 has been confirmed in preclinical studies to activate T cells, which are part of the immune system, and bring them into close proximity with antibody producing B cells and plasma cells to induce cell destruction. Since many autoimmune diseases involve B cells and plasma cells that produce autoantibodies, HBM7020 is expected to have broad efficacy against these diseases. 1xbet 후기 Pharmaceutical plans to advance the development of HBM7020 as a therapeutic agent for autoimmune diseases.

Under the terms of the agreement, 1xbet 후기 will pay Harbour BioMed a total of U.S. million in upfront and near-term milestones. Other payments are contingent on the achievement of specified development and commercial milestones. 1xbet 후기 will exclusively conduct development and commercialization worldwide, excluding Greater China, and will pay Harbour BioMed tiered royalties based on sales. 1xbet 후기 will fund all future development.

Makoto Inoue, president and representative director of 1xbet 후기 Pharmaceutical, noted, "1xbet 후기 is expanding our development pipeline in the autoimmune disease field by leveraging the antibody drug platform of our subsidiary Visterra, and the small molecule drug discovery platform of our subsidiary Jnana. HBM7020 is expected to demonstrate efficacy in a broad range of autoimmune diseases in which B cells play a major role in disease pathogenesis, and we hope to contribute further to the field of specialized autoimmune diseases and thereby benefit patients."

Dr. Jingsong Wang, founder, chairman, and CEO of Harbour BioMed commented, "We are delighted to collaborate with 1xbet 후기, a global healthcare leader renowned for its innovative approach to addressing unmet medical needs. This collaboration underscores the strength of Harbour BioMed's proprietary Harbour Mice^®and HBICE^®technology plat1xbet 후기ms, which enable the rapid development of fully human bispecific antibodies with optimized safety and efficacy profiles. By leveraging our unique capabilities, we are well-positioned to advance next-generation biotherapeutics that can make a meaningful difference in patients' lives worldwide."

About HBM7020

HBM7020 is a BCMAxCD3 bispecific antibody generated us1xbet 후기g Harbour BioMed's fully human HBICE^®bispecific technology and Harbour Mice^® plat1xbet 후기m. It is designed to crosslink target cells and T cells by binding to BCMA and CD3 on the cell surface, leading to potent T cell activation and targeted cell elimination. By incorporating dual anti-BCMA binding sites 1xbet 후기 enhanced cell targeting and monovalent-optimized CD3 activity to minimize cytokine release syndrome (CRS), HBM7020 has demonstrated potent cytotoxicity with broad therapeutic potential in both immunological and oncological diseases. In August 2023, HBM7020 obtained IND clearance from the National Medical Products Administration (NMPA) to commence a Phase I trial 1xbet 후기 cancer in China.

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1xbet 후기 is a total healthcare company that focuses on each individual's potential to enhance their well-being. Our medical-related business provides treatments and diagnostics for both physical and mental health. Our nutraceutical business supports daily health maintenance and improvement. Otsuka's unique products and services are based on scientific evidence, under the guidance of our corporate philosophy:1xbet 후기-people creating new products for better health worldwide.

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About Harbour BioMed

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics 1xbet 후기 immunology and oncology. The company is build1xbet 후기g a robust and differentiated pipel1xbet 후기e through 1xbet 후기ternal R&D capabilities, strategic global collaborations 1xbet 후기 co-discovery and co-development, and selective acquisitions.

Harbour BioMed's proprietary antibody technology plat1xbet 후기m, Harbour Mice^®, generates fully human monoclonal antibodies in both the conventional two heavy and two light chain (H2L2) 1xbet 후기mat and the heavy chain-only (HCAb) 1xbet 후기mat. Building upon HCAb antibodies, the HCAb-based immune cell engagers (HBICE^®) bispecific antibody technology enables tumor-kill1xbet 후기g effects that traditional comb1xbet 후기ation therapies cannot achieve. Additionally, the HCAb-based bispecific immune cell antagonist (HBICA^TM) technology empowers the development of innovative biologics 1xbet 후기 immunological and inflammatory diseases. By integrating Harbour Mice^®, HBICE^®, and HBICA^TMwith a single B-cell cloning plat1xbet 후기m, Harbour BioMed has built a highly efficient and distinctive antibody discovery engine 1xbet 후기 developing next-generation therapeutic antibodies. 1xbet 후기 more in1xbet 후기mation, please visitwww.harbourbiomed.com.